Opentargets Mcp Server

What is Opentargets Mcp Server?

An unofficial Model Context Protocol server for accessing Open Targets platform data to research gene-drug-disease associations. Developed by Augmented Nature, it provides six tools that query live Open Targets API data.

How to use Opentargets Mcp Server?

Install and build with npm install && npm run build, then run node build/index.js. Configure in MCP clients such as Claude Desktop by adding a JSON entry pointing to the built server script.

Key features of Opentargets Mcp Server

• Six verified tools working with live Open Targets API data
• Target and disease search with size control (1–500 results)
• Target-disease associations with evidence scores from 20+ databases
• Comprehensive gene/protein and disease profile details
• Resource templates using standardized URIs
• GraphQL-based queries with no authentication required

Use cases of Opentargets Mcp Server

• Cancer research workflow: search oncogenes, retrieve target details, find associated diseases, and get prioritized targets
• Drug discovery pipeline: search for diseases, retrieve disease profiles, and identify therapeutic targets

FAQ from Opentargets Mcp Server

What runtime does Opentargets Mcp Server require?

Node.js is required to run the server, as it is built and executed using npm and node commands.

Does Opentargets Mcp Server require authentication?

No, the Open Targets API does not require authentication and offers generous rate limits for research use.

What data sources does Opentargets Mcp Server use?

It integrates over 20 databases including ChEMBL, Ensembl, EFO, ClinVar, GWAS Catalog, UniProt, and Reactome.

How is data accessed in Opentargets Mcp Server?

Data is retrieved via GraphQL queries to the Open Targets platform API v4 (api.platform.opentargets.org/api/v4/graphql) using standardized identifiers (Ensembl gene IDs, EFO IDs, ChEMBL IDs).

Are there any known limits of Opentargets Mcp Server?

The README notes generous rate limits for research use but does not specify exact caps; tools have a default result size of 25 (max 500).