Liana MCP Server

What is Liana-MCP?

Liana-MCP is a natural language interface for single-cell RNA-Seq (scRNA-Seq) analysis that uses the Model Context Protocol (MCP) to connect with the Liana analysis library. It is designed for researchers and developers who want to perform scRNA-Seq tasks—such as reading/writing data, cell-cell communication inference, and plotting—using natural language commands within MCP-compatible clients.

How to use Liana-MCP?

Install via pip: pip install Liana-mcp. Run locally with liana-mcp run and configure your MCP client with "command": "liana-mcp", "args": ["run"]. For remote access, run Liana-mcp run --transport shttp --port 8000 and set the client URL to http://localhost:8000/mcp.

Key features of Liana-MCP

• IO module for reading and writing scRNA-Seq data
• Cell-cell communication inference methods
• Plotting module including circle plot and dotplot
• Natural language interface for scRNA-Seq analysis
• Compatible with AI clients, plugins, and agent frameworks

Use cases of Liana-MCP

• Perform scRNA-Seq cell cluster analysis using natural language in an AI client like Cherry Studio
• Enable agent developers to call Liana’s functions programmatically for custom applications
• Integrate Liana analysis into MCP-compatible agent frameworks such as Agno or plugins like Cline