dbSNP MCP Plugin

@mattshu0410

Repository

Basic information

About dbSNP MCP Plugin

My attempt at an MCP server for dbSNP.

#dbsnp#genetic-variant#mcp-plugin

dbSNP MCP Plugin config

No standard config provided

This server doesn't expose a parseable MCP config block in its README. See the repository for install instructions.

Repository

dbSNP MCP Plugin tools

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Overview

What is dbSNP MCP Plugin?

The dbSNP MCP Plugin is an MCP server that retrieves genetic variant information from NCBI’s dbSNP database directly in a development environment. It is intended for developers who need to query SNP details, search for variants, and obtain clinical significance data programmatically.

How to use dbSNP MCP Plugin?

Install the required dependencies with pip install mcp requests, then install the server using mcp install server.py. Optionally, add an NCBI API key for higher rate limits via mcp install server.py -v NCBI_API_KEY=your_api_key_here. Use the provided functions: get_snp_by_rs, search_snps, and get_snp_clinical_significance.

Key features of dbSNP MCP Plugin

Retrieve detailed information about a SNP by its rs ID
Search for SNPs using gene names, phenotypes, or other terms
Obtain clinical significance data for specific variants

Use cases of dbSNP MCP Plugin

Look up details of a known SNP (e.g., rs6311) for analysis
Find all SNPs associated with a gene like BRCA1
Check the clinical significance of a variant such as rs397507444

Frequently asked questions

What are the prerequisites for using dbSNP MCP Plugin?

You need Python 3.7+ and the MCP CLI tool. The required Python packages are `mcp` and `requests`.

How can I increase the request rate limit?

NCBI imposes a default limit of 3 requests per second. To raise it to 10 requests per second, obtain an NCBI API key from your NCBI account settings and pass it when installing the server.

Where does the data come from?

All variant information is fetched live from NCBI’s dbSNP database through its public API.

What should I do if I encounter errors?

Check your internet connection, verify that the rs ID format is correct, ensure your NCBI API key (if used) is valid, and inspect the error messages for specific API response details.

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