Unofficial Reactome MCP Server

@Augmented-Nature

代码仓库

基本信息

分类

其他

许可证

MIT license

传输方式

stdio

作者

Augmented-Nature

关于 Unofficial Reactome MCP Server

Model Context Protocol server for accessing Reactome pathway and systems biology data.

#reactome#mcp-server#biological-data

Unofficial Reactome MCP Server 配置

使用下面的配置,将此服务器添加到你的 MCP 客户端。

{
  "mcpServers": {
    "Reactome-MCP-Server": {
      "command": "node",
      "args": [
        "build/index.js"
      ]
    }
  }
}

Unofficial Reactome MCP Server 工具

工具列表暂未提供

当前收录暂时没有可展示的工具列表，不代表服务没有工具。请查阅项目文档了解支持的能力。

工具是从 README 中自动提取的。维护者可以在 ## Tools 标题下列出工具,即可填充这部分内容。

概览

What is Unofficial Reactome MCP Server 🧬?

It is a Model Context Protocol server that provides access to curated biological pathway and systems biology data from the Reactome database. Developed by Augmented Nature, it is designed for researchers and scientists exploring cellular processes, disease mechanisms, and drug targets.

How to use Unofficial Reactome MCP Server 🧬?

Install via npm (npm install), build (npm run build), then run with node build/index.js. Configure your MCP client (e.g., Claude Desktop) by adding a reactome-server entry that points to the built script. Use any of the eight available tools by sending JSON‑RPC requests with the specified arguments.

Key features of Unofficial Reactome MCP Server 🧬

Eight tools for searching and retrieving Reactome pathway data
Covers 2,500+ pathways, 25,000+ reactions, and 14,000+ proteins
Supports gene‑to‑pathway and disease‑associated pathway lookups
Provides pathway hierarchy, participants, reactions, and protein interactions
Cross‑references UniProt, ChEMBL, Ensembl, and other databases
TypeScript implementation with robust error handling and 30‑second timeouts

Use cases of Unofficial Reactome MCP Server 🧬

Systems biology workflow: search DNA repair pathways, retrieve details, and explore gene involvement
Disease mechanism research: find cancer‑related pathways and analyze their reactions and hierarchy
Drug discovery pipeline: map a drug target gene to pathways, examine protein interactions, and study participants

常见问题

Is this an official Reactome product?

No. It is an unofficial server developed independently by Augmented Nature. It uses the public Reactome Content Service API but is not affiliated with or endorsed by the Reactome project.

What are the system requirements?

You need Node.js installed. The server is built from TypeScript source using `npm install` and `npm run build`, then runs via `node build/index.js`.

Where does the data come from and is authentication required?

All data is fetched live from the Reactome Content Service REST API (`https://reactome.org/ContentService`, v79). No authentication is required for normal research use, and rate limits are generous.

What data coverage does the server offer?

It provides access to over 2,500 curated pathways, 25,000+ reactions, and 14,000+ proteins across 20+ species, including human, mouse, and rat. It covers signal transduction, metabolism, gene regulation, cell cycle, DNA repair, immune response, and disease mechanisms.

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