OFFX MCP Server

@uh-joan

Basic information

About OFFX MCP Server

No overview available yet

OFFX MCP Server config

Add this server to your MCP-compatible client using the configuration below.

{
  "mcpServers": {
    "offx-mcp-server": {
      "command": "npx",
      "args": [
        "offx-mcp-server"
      ]
    }
  }
}

OFFX MCP Server tools

`{ drug: string }`

`{ "drug": "everolimus" }`

`{ target_id?: string, action_id?: string, adverse_event_id?: string, page?: number }`

`{ "target_id": "123", "action_id": "456" }`

`{ drug_id?: string, target_id?: string, action_id?: string, page?: number, adverse_event_id?: string, ref_source_type?: string, alert_type?: string, alert_phase?: string, alert_level_evidence?: string, alert_onoff_target?: string, alert_severity?: string, alert_causality?: string, alert_species?: string, alert_date_from?: string, alert_date_to?: string, order_by_date?: string, order_by_adv?: string }`

You must provide **exactly one** of: `drug_id` or `target_id` (not both, not neither)

`{ "drug_id": "11204", "page": 1 }`

`{ drug_id?: string, adverse_event_id?: string, target_id?: string, action_id?: string }`

You must provide **either** `drug_id` (alone), **or** both `target_id` and `action_id` (together)

`{ "drug_id": "99402" }`

`{ drug_id: string, page: number, adverse_event_id?: string, ref_source_type?: string, alert_type?: string, alert_phase?: string, alert_level_evidence?: string, alert_severity?: string, alert_causality?: string, alert_species?: string, alert_date_from?: string, alert_date_to?: string }`

`{ "drug_id": "11204", "page": 1 }`

`{ adverse_event: string }`

`{ "adverse_event": "Anaemia" }`

`{ drug_id?: string, target_id?: string }`

`{ "drug_id": "12345" }`

`{ target: string }`

`{ "target": "ALK" }`

`{ target_id: string, action_id: string, page?: number, adverse_event_id?: string, ref_source_type?: string, alert_type?: string, alert_phase?: string, alert_level_evidence?: string, alert_onoff_target?: string, alert_severity?: string, alert_causality?: string, alert_species?: string, alert_date_from?: string, alert_date_to?: string }`

Both `target_id` and `action_id` are **required**

`{ "target_id": "158", "action_id": "15" }`

Overview

What is OFFX MCP Server?

OFFX MCP Server provides direct access to the OFFX (Target Safety) drug and safety database, allowing searches for drugs, adverse events, alerts, and scores. It is designed for researchers and developers needing drug safety data.

How to use OFFX MCP Server?

Install via npm (npm install @uh-joan/offx-mcp-server), set the OFFX_API_TOKEN environment variable, and run as an MCP server with npx offx-mcp-server or as an HTTP server with USE_HTTP=true. Configure it in Claude Desktop by adding the server to claude_desktop_config.json.

Key features of OFFX MCP Server

Search drugs by name or by target/action/adverse event
Retrieve alerts with extensive filter options
Get drug and target scores
Pagination support for large result sets
Structured JSON responses
Optional HTTP API mode for REST endpoints

Use cases of OFFX MCP Server

Drug safety research and adverse event monitoring
Finding target-drug and drug-target associations
Retrieving drug and class scores for safety assessment
Searching for alerts by phase, type, severity, or evidence level
Integrating drug safety data into clinical or research workflows

Frequently asked questions

What is the OFFX database?

The OFFX (Target Safety) database is a drug and safety database that the server queries for drugs, adverse events, alerts, and scores.

How do I authenticate with the server?

You need to set the environment variable `OFFX_API_TOKEN` with your OFFX API token.

Can I run this server in HTTP mode?

Yes, set `USE_HTTP=true` and optionally specify a `PORT` (default 3000) to run as an HTTP server with REST endpoints.

What filter parameters are available for alerts?

Alerts support filters such as `adverse_event_id`, `alert_type`, `alert_phase`, `ref_source_type`, `alert_level_evidence`, `alert_onoff_target`, `alert_severity`, and more. Values must use OFFX-API compatible formats (e.g., comma-separated numbers for multiple values).

How do I paginate results?

Include a `page` parameter (integer) in your requests. It defaults to 1 if not specified.

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