GWAS Catalog MCP Server

@koido

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ライセンス

Apache-2.0

トランスポート

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作者

koido

投稿者

Masaru Koido

GWAS Catalog MCP Server について

概要はまだありません

#gwas#bioinformatics

GWAS Catalog MCP Server の設定

以下の設定を使って、このサーバーを MCP 対応クライアントに追加してください。

{
  "mcpServers": {
    "gwas-catalog-mcp": {
      "command": "uv",
      "args": [
        "sync"
      ]
    }
  }
}

GWAS Catalog MCP Server のツール

ツール一覧はまだありません

この掲載には表示できるツール一覧がまだありません。サーバーにツールがないという意味ではありません。対応機能はプロジェクトのドキュメントをご確認ください。

ツールは README から自動的に抽出されます。メンテナーは ## Tools という見出しの下に記載することで、このタブに反映できます。

概要

What is GWAS Catalog MCP Server?

This MCP server provides a programmatic interface to the GWAS Catalog REST API, enabling access to GWAS study, variant, trait, and association data. It automatically handles large result sets by offering both in-memory results and file-based storage options.

How to use GWAS Catalog MCP Server?

Install dependencies with uv sync, activate the virtual environment (. .venv/bin/activate), then run the server with uv run server.py. The server exposes a single tool, GWAS_catalog, with multiple endpoints for querying different data types. All endpoints accept common parameters like max_items_in_memory, output_dir, and force_to_file.

Key features of GWAS Catalog MCP Server

Provides programmatic access to GWAS Catalog REST API
Automatic handling of large result sets with file storage
Queries studies, variants, traits, and associations
Supports genome-wide significance filtering (p ≤ 5e-8)
Configurable memory limit and output directory
Removes _links fields from API responses by default

Use cases of GWAS Catalog MCP Server

Retrieve study details and associations for a given study identifier
Search variants in a genomic region and filter by trait
Fetch all associations for a specific variant (with significance flag)
Obtain studies and associations linked to a trait (EFO ID)
Rank top variants associated with a trait

よくある質問

What happens when results exceed the memory limit?

A subset of results is returned in the `items` field, `is_complete` is set to `false`, and the complete dataset is automatically saved to a file specified in the `output_file` field.

What dependencies are required to run the server?

The server requires `uv`, `mcp[cli]`, `fastmcp`, and `requests`. Install them with `uv sync`.

Can I force all results to be written to a file?

Yes. Set the `force_to_file` parameter to `true` to always save results to a file regardless of size. Alternatively, use `force_no_file` to never write to file.

Which endpoints use the GWAS Summary Statistics API instead of the main REST API?

The `get_region-trait-associations` endpoint and other endpoints marked as "uses GWAS Summary Statistics API" access `https://www.ebi.ac.uk/gwas/summary-statistics/api`.

Does the server filter results for genome-wide significance?

For endpoints that process p-values (e.g., `get_associations_from_variant`), only results with `is_gwas_significant: true` (p ≤ 5e-8) are returned. The metadata includes `significant_items` count.

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